Dual Action of Mexiletine and Its Pyrroline Derivatives as Skeletal Muscle Sodium Channel Blockers and Anti-oxidant Compounds: Toward Novel Therapeutic Potential

Mexiletine (Mex) has been recently appointed as an orphan-drug in myotonic-syndromes, being a potent use-dependent blocker of skeletal-muscle sodium channels (Na(V)1.4). Available evidences about a potential anti-oxidant effect of Mex and its tetramethyl-pyrroline-derivatives in vivo, suggest the po...

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Detalles Bibliográficos
Autores principales: De Bellis, Michela, Sanarica, Francesca, Carocci, Alessia, Lentini, Giovanni, Pierno, Sabata, Rolland, Jean-François, Conte Camerino, Diana, De Luca, Annamaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770958/
https://www.ncbi.nlm.nih.gov/pubmed/29379434
http://dx.doi.org/10.3389/fphar.2017.00907

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770958/
https://www.ncbi.nlm.nih.gov/pubmed/29379434
http://dx.doi.org/10.3389/fphar.2017.00907

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