Drug Repurposing Screening Identifies Tioconazole as an ATG4 Inhibitor that Suppresses Autophagy and Sensitizes Cancer Cells to Chemotherapy

Background: Tumor cells require proficient autophagy to meet high metabolic demands and resist chemotherapy, which suggests that reducing autophagic flux might be an attractive route for cancer therapy. However, this theory in clinical cancer research remains controversial due to the limited number...

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Detalles Bibliográficos
Autores principales: Liu, Pei-Feng, Tsai, Kun-Lin, Hsu, Chien-Jen, Tsai, Wei-Lun, Cheng, Jin-Shiung, Chang, Hsueh-Wei, Shiau, Chung-Wai, Goan, Yih-Gang, Tseng, Ho-Hsing, Wu, Chih-Hsuan, Reed, John C., Yang, Lee-Wei, Shu, Chih-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771097/
https://www.ncbi.nlm.nih.gov/pubmed/29344310
http://dx.doi.org/10.7150/thno.22012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771097/
https://www.ncbi.nlm.nih.gov/pubmed/29344310
http://dx.doi.org/10.7150/thno.22012

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