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Molecular and functional signatures in a novel Alzheimer’s disease mouse model assessed by quantitative proteomics
BACKGROUND: Alzheimer’s disease (AD), the most common neurodegenerative disorder, is characterized by the deposition of extracellular amyloid plaques and intracellular neurofibrillary tangles. To understand the pathological mechanisms underlying AD, developing animal models that completely encompass...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771139/ https://www.ncbi.nlm.nih.gov/pubmed/29338754 http://dx.doi.org/10.1186/s13024-017-0234-4 |