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Structural alteration of DNA induced by viral protein R of HIV-1 triggers the DNA damage response
BACKGROUND: Viral protein R (Vpr) is an accessory protein of HIV-1, which is potentially involved in the infection of macrophages and the induction of the ataxia-telangiectasia and Rad3-related protein (ATR)-mediated DNA damage response (DDR). It was recently proposed that the SLX4 complex of struct...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771197/ https://www.ncbi.nlm.nih.gov/pubmed/29338752 http://dx.doi.org/10.1186/s12977-018-0391-8 |