Cargando…

Synthesis, Biological Evaluation and Modeling Studies of New Pyrido[3,4-b]indole Derivatives as Broad-Spectrum Potent Anticancer Agents

OBJECTIVE: There is an urgent need drugs against particularly difficult to treat solid tumors such as pancreatic, triple negative breast, lung, colon, metastatic prostate cancers and melanoma. Thus, the objective of this study was to synthesize compounds based computational modeling that indicated t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Patil, Shivaputra A, Addo, James K, Deokar, Hemantkumar, Sun, Shan, Wang, Jin, Li, Wei, Suttle, D Parker, Wang, Wei, Zhang, Ruiwen, Buolamwini, John K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771418/ https://www.ncbi.nlm.nih.gov/pubmed/29354330 http://dx.doi.org/10.4172/2169-0138.1000143

Ejemplares similares

Inhibiting β-Catenin by β-Carboline-Type MDM2 Inhibitor for Pancreatic Cancer Therapy
por: Qin, Jiang-Jiang, et al.
Publicado: (2018)

Targeting MDM2 for Neuroblastoma Therapy: In Vitro and In Vivo Anticancer Activity and Mechanism of Action
por: Wang, Wei, et al.
Publicado: (2020)

Targeted Brain Tumor Therapy by Inhibiting the MDM2 Oncogene: In Vitro and In Vivo Antitumor Activity and Mechanism of Action
por: Punganuru, Surendra R., et al.
Publicado: (2020)

Design, synthesis, apoptotic, and antiproliferative effects of 5-chloro-3- (2-methoxyvinyl)-indole-2-carboxamides and pyrido[3,4-b]indol-1-ones as potent EGFR(WT/)EGFR(T790M) inhibitors
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2023)

Morita–Baylis–Hillman reaction of 3-formyl-9H-pyrido[3,4-b]indoles and fluorescence studies of the products
por: Devi, Nisha, et al.
Publicado: (2022)

5-Benzyl-5H-pyrido[3,2-b]indole
por: Letessier, Julien, et al.
Publicado: (2011)

Biological evaluation and structure activity relationship of 9-methyl-1-phenyl-9H-pyrido[3,4-b]indole derivatives as anti-leishmanial agents
por: Ashok, Penta, et al.
Publicado: (2019)

From Quinoxaline, Pyrido[2,3-b]pyrazine and Pyrido[3,4-b]pyrazine to Pyrazino-Fused Carbazoles and Carbolines
por: Lassagne, Frédéric, et al.
Publicado: (2018)

Dehydrative Transformation of Spirooxindoles to Pyrido[2,3-b]indoles via POCl(3)
por: Kolle, Shivalinga, et al.
Publicado: (2019)

Manganese dioxide mediated one-pot synthesis of methyl 9H-pyrido[3,4-b]indole-1-carboxylate: Concise synthesis of alangiobussinine
por: Baiget, Jessica, et al.
Publicado: (2011)

A Facile Synthesis of 3-Substituted 9H-Pyrido[3,4-b]indol-1(2H)-one Derivatives from 3-Substituted β-Carbolines
por: Lin, Guowu, et al.
Publicado: (2010)

Studies of Interaction Mechanism between Pyrido [3,4-d] Pyrimidine Inhibitors and Mps1
por: Xing, Cheng, et al.
Publicado: (2021)

2-[2-(Methylamino)benzoyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one
por: Li, Lin, et al.
Publicado: (2010)

Design, Synthesis, and Potent Anticancer Activity of Novel Indole-Based Bcl-2 Inhibitors
por: Almehdi, Ahmed M., et al.
Publicado: (2023)

Medicinal chemistry perspective of pyrido[2,3-d]pyrimidines as anticancer agents
por: Kumar, Adarsh, et al.
Publicado: (2023)

The Gramine Route to Pyrido[4,3-b]indol-3-ones – Identification of a New Cytotoxic Lead
por: Wollein, Uwe, et al.
Publicado: (2011)

Overcoming the imatinib-resistant BCR-ABL mutants with new ureidobenzothiazole chemotypes endowed with potent and broad-spectrum anticancer activity
por: El-Damasy, Ashraf K., et al.
Publicado: (2023)

Discovery and cellular stress pathway analysis of 1,4-naphthoquinone derivatives with novel, highly potent broad-spectrum anticancer activity
por: Ghosh, Sajal K., et al.
Publicado: (2018)

Exploration of Pyrido[3,4-d]pyrimidines as Antagonists of the Human Chemokine Receptor CXCR2
por: Van Hoof, Max, et al.
Publicado: (2023)

12-(4-Methoxybenzoyl)-2-methylbenzo[f]pyrido[1,2-a]indole-6,11-dione
por: Novina, J. Josephine, et al.
Publicado: (2012)

Induction of DNA Recombination by Activated 3‐Amino‐1‐methyl‐5H‐pyrido[4,3‐b]indole
por: Hiramoto, Kazuyuki, et al.
Publicado: (1995)

Asymmetric construction of pyrido[1,2-a]-1H-indole derivatives via a gold-catalyzed cycloisomerization
por: Jiang, Feng, et al.
Publicado: (2020)

Crystal structure of 4-(4b,8a-dihydro-9H-pyrido[3,4-b]indol-1-yl)-7-methyl-2H-chromen-2-one
por: Samundeeswari, S., et al.
Publicado: (2017)

JKA97, a Novel Benzylidene Analog of Harmine, Exerts Anti-Cancer Effects by Inducing G1 Arrest, Apoptosis, and p53-Independent Up-Regulation of p21
por: Yang, Xinyi, et al.
Publicado: (2012)

Design, synthesis and biological evaluation of 9-aryl-5H-pyrido[4,3-b]indole derivatives as potential tubulin polymerization inhibitors
por: Shi, Lingyu, et al.
Publicado: (2022)

New derivatives of hydrogenated pyrido[4,3-b]indoles as potential neuroprotectors: Synthesis, biological testing and solubility in pharmaceutically relevant solvents
por: Blokhina, Svetlana, et al.
Publicado: (2018)

Identification of Novel Bisbenzimidazole Derivatives as Anticancer Vacuolar (H(+))-ATPase Inhibitors †
por: Patil, Renukadevi, et al.
Publicado: (2017)

Broad-Spectrum Anticancer Activity and Pharmacokinetic Properties of a Prenyloxy-Substituted Indeno[1,2-b]indole Derivative, Discovered as CK2 Inhibitor
por: El-Awaad, Ehab, et al.
Publicado: (2021)

MicroRNA-34a: Potent Tumor Suppressor, Cancer Stem Cell Inhibitor, and Potential Anticancer Therapeutic
por: Li, Wen (Jess), et al.
Publicado: (2021)

Naphthoquine: A Potent Broad-Spectrum Anti-Coronavirus Drug In Vitro
por: Song, Yabin, et al.
Publicado: (2022)

High-Throughput Screening and Identification of Potent Broad-Spectrum Inhibitors of Coronaviruses
por: Shen, Liang, et al.
Publicado: (2019)

TFA-catalyzed Q-Tube Reactor-Assisted Strategy for the Synthesis of Pyrido[1,2-b][1,2,4]triazine and Pyrido[1′,2′:2,3][1,2,4]triazino[5,6-b]indole Derivatives
por: Ibrahim, Hamada Mohamed, et al.
Publicado: (2021)

Three Dimensional Quantitative Structure-Activity Relationship of 5H-Pyrido[4,3-b]indol-4-carboxamide JAK2 Inhibitors
por: Wu, Xiaoyun, et al.
Publicado: (2013)

Discovery of Potent Broad Spectrum Antivirals Derived from Marine Actinobacteria
por: Raveh, Avi, et al.
Publicado: (2013)

Indole-fused benzooxazepines: a new structural class of anticancer agents
por: Singh, Ashok K, et al.
Publicado: (2017)

Anticancer evaluation and molecular modeling of multi-targeted kinase inhibitors based pyrido[2,3-d]pyrimidine scaffold
por: Elzahabi, Heba S. A., et al.
Publicado: (2018)

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors
por: Bavetsias, Vassilios, et al.
Publicado: (2016)

ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker
por: Chen, Yuning, et al.
Publicado: (2021)

Indole and 2,4-Thiazolidinedione conjugates as potential anticancer modulators
por: Corigliano, Domenica M., et al.
Publicado: (2018)

Burkholderia gladioli strain KJ-34 exhibits broad-spectrum antifungal activity
por: Yang, Chunnan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_jvrlho4k62pacvioe54t07f1sf