Targeted Elimination of Immunodominant B Cells Drives the Germinal Center Reaction toward Subdominant Epitopes

Rapidly evolving pathogens such as HIV or influenza can quickly mutate their antigenic profiles, reducing the efficacy of conventional vaccines. Despite this challenge, functionally required epitopes are highly conserved among heterologous viral strains and represent a key vulnerability that could b...

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Detalles Bibliográficos
Autores principales: Silva, Murillo, Nguyen, Thao H., Philbrook, Phaethon, Chu, Matthew, Sears, Olivia, Hatfield, Stephen, Abbott, Robert K., Kelsoe, Garnett, Sitkovsky, Michail V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771444/
https://www.ncbi.nlm.nih.gov/pubmed/29281817
http://dx.doi.org/10.1016/j.celrep.2017.12.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771444/
https://www.ncbi.nlm.nih.gov/pubmed/29281817
http://dx.doi.org/10.1016/j.celrep.2017.12.014

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