Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA

Many studies have revealed pathways of epigenetic gene silencing by Polycomb Repressive Complex 2 (PRC2) in vivo, but understanding molecular mechanisms requires biochemistry. Here we analyze reconstituted human PRC2-nucleosome complexes. Histone modifications, the H3K27M cancer mutation, and inclus...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Xueyin, Paucek, Richard D., Gooding, Anne R., Brown, Zachary Z., Ge, Eva J., Muir, Tom W., Cech, Thomas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771497/
https://www.ncbi.nlm.nih.gov/pubmed/29058709
http://dx.doi.org/10.1038/nsmb.3487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771497/
https://www.ncbi.nlm.nih.gov/pubmed/29058709
http://dx.doi.org/10.1038/nsmb.3487

Ejemplares similares