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Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA

Many studies have revealed pathways of epigenetic gene silencing by Polycomb Repressive Complex 2 (PRC2) in vivo, but understanding molecular mechanisms requires biochemistry. Here we analyze reconstituted human PRC2-nucleosome complexes. Histone modifications, the H3K27M cancer mutation, and inclus...

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Detalles Bibliográficos
Autores principales:	Wang, Xueyin, Paucek, Richard D., Gooding, Anne R., Brown, Zachary Z., Ge, Eva J., Muir, Tom W., Cech, Thomas R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771497/ https://www.ncbi.nlm.nih.gov/pubmed/29058709 http://dx.doi.org/10.1038/nsmb.3487

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