A non-linear pharmacokinetic-pharmacodynamic relationship of metformin in healthy volunteers: An open-label, parallel group, randomized clinical study

BACKGROUND: The aim of this study was to explore the pharmacokinetic-pharmacodynamic (PK-PD) relationship of metformin on glucose levels after the administration of 250 mg and 1000 mg of metformin in healthy volunteers. METHODS: A total of 20 healthy male volunteers were randomized to receive two do...

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Detalles Bibliográficos
Autores principales: Chung, Hyewon, Oh, Jaeseong, Yoon, Seo Hyun, Yu, Kyung-Sang, Cho, Joo-Youn, Chung, Jae-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771593/
https://www.ncbi.nlm.nih.gov/pubmed/29342199
http://dx.doi.org/10.1371/journal.pone.0191258

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771593/
https://www.ncbi.nlm.nih.gov/pubmed/29342199
http://dx.doi.org/10.1371/journal.pone.0191258

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