The polymethoxy flavonoid sudachitin suppresses inflammatory bone destruction by directly inhibiting osteoclastogenesis due to reduced ROS production and MAPK activation in osteoclast precursors

Inflammatory bone diseases, including rheumatoid arthritis, periodontitis and peri-implantitis, are associated not only with the production of inflammatory cytokines but also with local oxidative status, which is defined by intracellular reactive oxygen species (ROS). Osteoclast differentiation has...

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Detalles Bibliográficos
Autores principales: Ohyama, Yoko, Ito, Junta, Kitano, Victor J., Shimada, Jun, Hakeda, Yoshiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771597/
https://www.ncbi.nlm.nih.gov/pubmed/29342179
http://dx.doi.org/10.1371/journal.pone.0191192

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771597/
https://www.ncbi.nlm.nih.gov/pubmed/29342179
http://dx.doi.org/10.1371/journal.pone.0191192

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