Inhibiting TGF-beta signaling preserves the function of highly activated, in vitro expanded natural killer cells in AML and colon cancer models

Natural killer cells harnessed from healthy individuals can be expanded ex vivo using various platforms to produce large doses for adoptive transfer into cancer patients. During such expansion, NK cells are increasingly activated and more efficient at killing cancer cells. Adoptive transfer however...

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Detalles Bibliográficos
Autores principales: Otegbeye, Folashade, Ojo, Evelyn, Moreton, Stephen, Mackowski, Nathan, Lee, Dean A., de Lima, Marcos, Wald, David N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771627/
https://www.ncbi.nlm.nih.gov/pubmed/29342200
http://dx.doi.org/10.1371/journal.pone.0191358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771627/
https://www.ncbi.nlm.nih.gov/pubmed/29342200
http://dx.doi.org/10.1371/journal.pone.0191358

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