The ferroptosis inducer erastin irreversibly inhibits system x(c)− and synergizes with cisplatin to increase cisplatin’s cytotoxicity in cancer cells

System x(c)(−) was recently described as the most upstream node in a novel form of regulated necrotic cell death, called ferroptosis. In this context, the small molecule erastin was reported to target and inhibit system x(c)(−), leading to cysteine starvation, glutathione depletion and consequently...

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Detalles Bibliográficos
Autores principales: Sato, Mami, Kusumi, Ryosuke, Hamashima, Shinji, Kobayashi, Sho, Sasaki, Satoru, Komiyama, Yuhei, Izumikawa, Takuji, Conrad, Marcus, Bannai, Shiro, Sato, Hideyo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772355/
https://www.ncbi.nlm.nih.gov/pubmed/29343855
http://dx.doi.org/10.1038/s41598-018-19213-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772355/
https://www.ncbi.nlm.nih.gov/pubmed/29343855
http://dx.doi.org/10.1038/s41598-018-19213-4

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