Targeting murine leukemic stem cells by antibody functionalized mesoporous silica nanoparticles

Acute leukemia is initiated and maintained by leukemia stem cells (LSCs) and therefore there is great interest to develop innovative therapeutic approaches which target LSCs. Here we show that mesoporous silica nanoparticles (MSNs) functionalized with succinic anhydride, tagged with an anti-B220 ant...

Descripción completa

Detalles Bibliográficos
Autores principales: Mandal, Tamoghna, Beck, Michaela, Kirsten, Nicole, Lindén, Mika, Buske, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772366/
https://www.ncbi.nlm.nih.gov/pubmed/29343865
http://dx.doi.org/10.1038/s41598-017-18932-4
_version_ 1783293399464411136
author Mandal, Tamoghna
Beck, Michaela
Kirsten, Nicole
Lindén, Mika
Buske, Christian
author_facet Mandal, Tamoghna
Beck, Michaela
Kirsten, Nicole
Lindén, Mika
Buske, Christian
author_sort Mandal, Tamoghna
collection PubMed
description Acute leukemia is initiated and maintained by leukemia stem cells (LSCs) and therefore there is great interest to develop innovative therapeutic approaches which target LSCs. Here we show that mesoporous silica nanoparticles (MSNs) functionalized with succinic anhydride, tagged with an anti-B220 antibody and loaded with the anthracycline daunorubicin are efficiently incorporated into murine B220-positive AML LSCs and preferentially kill these cells in comparison to B220-negative AML LSCs in vitro. Furthermore, short – term treatment of the AML LSCs with these MSNs before transplant significantly delayed leukemia development in recipient mice. These data demonstrate that targeting of AML LSCs can be improved by using functionalized and antigen directed MSNs as carriers for anti-leukemic drugs.
format Online
Article
Text
id pubmed-5772366
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-57723662018-01-26 Targeting murine leukemic stem cells by antibody functionalized mesoporous silica nanoparticles Mandal, Tamoghna Beck, Michaela Kirsten, Nicole Lindén, Mika Buske, Christian Sci Rep Article Acute leukemia is initiated and maintained by leukemia stem cells (LSCs) and therefore there is great interest to develop innovative therapeutic approaches which target LSCs. Here we show that mesoporous silica nanoparticles (MSNs) functionalized with succinic anhydride, tagged with an anti-B220 antibody and loaded with the anthracycline daunorubicin are efficiently incorporated into murine B220-positive AML LSCs and preferentially kill these cells in comparison to B220-negative AML LSCs in vitro. Furthermore, short – term treatment of the AML LSCs with these MSNs before transplant significantly delayed leukemia development in recipient mice. These data demonstrate that targeting of AML LSCs can be improved by using functionalized and antigen directed MSNs as carriers for anti-leukemic drugs. Nature Publishing Group UK 2018-01-17 /pmc/articles/PMC5772366/ /pubmed/29343865 http://dx.doi.org/10.1038/s41598-017-18932-4 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Mandal, Tamoghna
Beck, Michaela
Kirsten, Nicole
Lindén, Mika
Buske, Christian
Targeting murine leukemic stem cells by antibody functionalized mesoporous silica nanoparticles
title Targeting murine leukemic stem cells by antibody functionalized mesoporous silica nanoparticles
title_full Targeting murine leukemic stem cells by antibody functionalized mesoporous silica nanoparticles
title_fullStr Targeting murine leukemic stem cells by antibody functionalized mesoporous silica nanoparticles
title_full_unstemmed Targeting murine leukemic stem cells by antibody functionalized mesoporous silica nanoparticles
title_short Targeting murine leukemic stem cells by antibody functionalized mesoporous silica nanoparticles
title_sort targeting murine leukemic stem cells by antibody functionalized mesoporous silica nanoparticles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772366/
https://www.ncbi.nlm.nih.gov/pubmed/29343865
http://dx.doi.org/10.1038/s41598-017-18932-4
work_keys_str_mv AT mandaltamoghna targetingmurineleukemicstemcellsbyantibodyfunctionalizedmesoporoussilicananoparticles
AT beckmichaela targetingmurineleukemicstemcellsbyantibodyfunctionalizedmesoporoussilicananoparticles
AT kirstennicole targetingmurineleukemicstemcellsbyantibodyfunctionalizedmesoporoussilicananoparticles
AT lindenmika targetingmurineleukemicstemcellsbyantibodyfunctionalizedmesoporoussilicananoparticles
AT buskechristian targetingmurineleukemicstemcellsbyantibodyfunctionalizedmesoporoussilicananoparticles

Ejemplares similares