Targeted inhibitors of P-glycoprotein increase chemotherapeutic-induced mortality of multidrug resistant tumor cells

Overexpression of ATP-binding cassette (ABC) transporters is often linked to multidrug resistance (MDR) in cancer chemotherapies. P-glycoprotein (P-gp) is one of the best studied drug transporters associated with MDR. There are currently no approved drugs available for clinical use in cancer chemoth...

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Detalles Bibliográficos
Autores principales: Nanayakkara, Amila K., Follit, Courtney A., Chen, Gang, Williams, Noelle S., Vogel, Pia D., Wise, John G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772368/
https://www.ncbi.nlm.nih.gov/pubmed/29343829
http://dx.doi.org/10.1038/s41598-018-19325-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772368/
https://www.ncbi.nlm.nih.gov/pubmed/29343829
http://dx.doi.org/10.1038/s41598-018-19325-x

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