A novel α-conopeptide Eu1.6 inhibits N-type (Ca(V)2.2) calcium channels and exhibits potent analgesic activity

We here describe a novel α-conopeptide, Eu1.6 from Conus eburneus, which exhibits strong anti-nociceptive activity by an unexpected mechanism of action. Unlike other α-conopeptides that largely target nicotinic acetylcholine receptors (nAChRs), Eu1.6 displayed only weak inhibitory activity at the α3...

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Detalles Bibliográficos
Autores principales: Liu, Zhuguo, Bartels, Peter, Sadeghi, Mahsa, Du, Tianpeng, Dai, Qing, Zhu, Cui, Yu, Shuo, Wang, Shuo, Dong, Mingxin, Sun, Ting, Guo, Jiabin, Peng, Shuangqing, Jiang, Ling, Adams, David J., Dai, Qiuyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772529/
https://www.ncbi.nlm.nih.gov/pubmed/29343689
http://dx.doi.org/10.1038/s41598-017-18479-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772529/
https://www.ncbi.nlm.nih.gov/pubmed/29343689
http://dx.doi.org/10.1038/s41598-017-18479-4

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