Phosphorylation induced cochaperone unfolding promotes kinase recruitment and client class-specific Hsp90 phosphorylation

During the Hsp90-mediated chaperoning of protein kinases, the core components of the machinery, Hsp90 and the cochaperone Cdc37, recycle between different phosphorylation states that regulate progression of the chaperone cycle. We show that Cdc37 phosphorylation at Y298 results in partial unfolding...

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Detalles Bibliográficos
Autores principales: Bachman, Ashleigh B., Keramisanou, Dimitra, Xu, Wanping, Beebe, Kristin, Moses, Michael A., Vasantha Kumar, M. V., Gray, Geoffrey, Noor, Radwan Ebna, van der Vaart, Arjan, Neckers, Len, Gelis, Ioannis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772613/
https://www.ncbi.nlm.nih.gov/pubmed/29343704
http://dx.doi.org/10.1038/s41467-017-02711-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772613/
https://www.ncbi.nlm.nih.gov/pubmed/29343704
http://dx.doi.org/10.1038/s41467-017-02711-w

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