Mechanically-sensitive miRNAs bias human mesenchymal stem cell fate via mTOR signalling

Mechanotransduction is a strong driver of mesenchymal stem cell (MSC) fate. In vitro, variations in matrix mechanics invoke changes in MSC proliferation, migration and differentiation. However, when incorporating MSCs within injectable, inherently soft hydrogels, this dominance over MSC response sub...

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Detalles Bibliográficos
Autores principales: Frith, Jessica E., Kusuma, Gina D., Carthew, James, Li, Fanyi, Cloonan, Nicole, Gomez, Guillermo A., Cooper-White, Justin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772625/
https://www.ncbi.nlm.nih.gov/pubmed/29343687
http://dx.doi.org/10.1038/s41467-017-02486-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772625/
https://www.ncbi.nlm.nih.gov/pubmed/29343687
http://dx.doi.org/10.1038/s41467-017-02486-0

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