Cargando…

Mechanically-sensitive miRNAs bias human mesenchymal stem cell fate via mTOR signalling

Mechanotransduction is a strong driver of mesenchymal stem cell (MSC) fate. In vitro, variations in matrix mechanics invoke changes in MSC proliferation, migration and differentiation. However, when incorporating MSCs within injectable, inherently soft hydrogels, this dominance over MSC response sub...

Descripción completa

Detalles Bibliográficos
Autores principales:	Frith, Jessica E., Kusuma, Gina D., Carthew, James, Li, Fanyi, Cloonan, Nicole, Gomez, Guillermo A., Cooper-White, Justin J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772625/ https://www.ncbi.nlm.nih.gov/pubmed/29343687 http://dx.doi.org/10.1038/s41467-017-02486-0

Ejemplares similares

mTOR Links Environmental Signals to T Cell Fate Decisions
por: Chapman, Nicole M., et al.
Publicado: (2015)

Emerging Role of mTOR Signaling-Related miRNAs in Cardiovascular Diseases
por: Samidurai, Arun, et al.
Publicado: (2018)

Inhibition of the AKT/mTOR pathway negatively regulates PTEN expression via miRNAs: Effect of Akt/mTOR inhibition on PTEN expression
por: Wan, Linyan, et al.
Publicado: (2022)

The Fate of the Tumor in the Hands of Microenvironment: Role of TAMs and mTOR Pathway
por: Soave, Danilo Figueiredo, et al.
Publicado: (2016)

DDIT4 regulates mesenchymal stem cell fate by mediating between HIF1α and mTOR signalling
por: Gharibi, Borzo, et al.
Publicado: (2016)

Revisiting mTOR and Epithelial–Mesenchymal Transition
por: Herrerias, Mariana M., et al.
Publicado: (2020)

Hirudin inhibits glioma growth through mTOR‐regulated autophagy
por: Ma, Ying, et al.
Publicado: (2023)

Mammalian Target of Rapamycin (mTOR) Signaling at the Crossroad of Muscle Fiber Fate in Sarcopenia
por: Sirago, Giuseppe, et al.
Publicado: (2022)

microRNAs calibrate T cell responses by regulating mTOR
por: Merkenschlager, Matthias, et al.
Publicado: (2015)

mTOR signaling-related MicroRNAs and Cancer involvement
por: WANG, Ping, et al.
Publicado: (2018)

The roles and mechanisms of circular RNAs related to mTOR in cancers
por: Cao, Chunli, et al.
Publicado: (2022)

mTOR sends T cells on their way
por: LeBrasseur, Nicole
Publicado: (2008)

Chemical Inhibitors and microRNAs (miRNA) Targeting the Mammalian Target of Rapamycin (mTOR) Pathway: Potential for Novel Anticancer Therapeutics
por: AlQurashi, Naif, et al.
Publicado: (2013)

Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR
por: Sempou, Emily, et al.
Publicado: (2022)

mTOR Pathway and mTOR Inhibitors in Head and Neck Cancer
por: Gao, Wei, et al.
Publicado: (2012)

Re-thinking miRNA-mRNA interactions: Intertwining issues confound target discovery
por: Cloonan, Nicole
Publicado: (2015)

Myelination and mTOR
por: Figlia, Gianluca, et al.
Publicado: (2017)

mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges
por: Zou, Zhilin, et al.
Publicado: (2020)

Interaction of lncRNAs with mTOR in colorectal cancer: a systematic review
por: Moslehian, Marziyeh Sadat, et al.
Publicado: (2023)

miRNAs Alter T Helper 17 Cell Fate in the Pathogenesis of Autoimmune Diseases
por: Huang, Junxia, et al.
Publicado: (2021)

mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy
por: Tian, Tian, et al.
Publicado: (2019)

Regulation of Osteoclast Growth and Fusion by mTOR/raptor and mTOR/rictor/Akt
por: Tiedemann, Kerstin, et al.
Publicado: (2017)

Escaping mTOR inhibition for cancer therapy: Tumor suppressor functions of mTOR
por: Villar, Victor H., et al.
Publicado: (2017)

Overcoming mTOR Resistance Mutations with a New Generation mTOR Inhibitor
por: Rodrik-Outmezguine, Vanessa S., et al.
Publicado: (2016)

Author Correction: Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR
por: Sempou, Emily, et al.
Publicado: (2023)

mTOR and lysosome regulation
por: Puertollano, Rosa
Publicado: (2014)

mTOR, autophagy, and reprogramming
por: Tang, Bor Luen
Publicado: (2014)

Targeting glutaminase and mTOR
por: Tanaka, Kazuhiro, et al.
Publicado: (2015)

mTOR in cerebrovascular disease
por: Van Skike, Candice E., et al.
Publicado: (2019)

mTOR and Tumor Cachexia
por: Duval, Adrian P., et al.
Publicado: (2018)

Double agent mTOR
por: Danzer, Steve C.
Publicado: (2019)

mTOR in Human Diseases
por: Dormond, Olivier
Publicado: (2019)

Commentary: Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor
por: Renna, Maurizio
Publicado: (2016)

Differential expression of genes related to calcineurin and mTOR signaling and regulatory miRNAs in peripheral blood from kidney recipients under tacrolimus-based therapy
por: Bonezi, Vivian, et al.
Publicado: (2020)

Resveratrol, curcumin, paclitaxel and miRNAs mediated regulation of PI3K/Akt/mTOR pathway: go four better to treat bladder cancer
por: Khan, Khushbukhat, et al.
Publicado: (2020)

mTOR Overactivation in Mesenchymal cells Aggravates CCl(4)− Induced liver Fibrosis
por: Shan, Lanlan, et al.
Publicado: (2016)

mTOR and ROS regulation by anethole on adipogenic differentiation in human mesenchymal stem cells
por: Rhee, Yun-Hee, et al.
Publicado: (2018)

Individual response to mTOR inhibition in delaying replicative senescence of mesenchymal stromal cells
por: Antonioli, Eliane, et al.
Publicado: (2019)

The importance of cellular and exosomal miRNAs in mesenchymal stem cell osteoblastic differentiation
por: Shirazi, Sajjad, et al.
Publicado: (2021)

Synergic Functions of miRNAs Determine Neuronal Fate of Adult Neural Stem Cells
por: Pons-Espinal, Meritxell, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_a7hefs6q79edags53l444kkesq