Mitochondrial DNA damage and subsequent activation of Z-DNA binding protein 1 links oxidative stress to inflammation in epithelial cells

This report identifies mitochondrial DNA (mtDNA) as a target and active mediator that links low-level oxidative stress to inflammatory response in pulmonary epithelial cells. Extrusion of mtDNA into the bronchoalveolar lavage fluid occurs as an early event in mice subjected to cigarette smoke injury...

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Detalles Bibliográficos
Autores principales: Szczesny, Bartosz, Marcatti, Michela, Ahmad, Akbar, Montalbano, Mauro, Brunyánszki, Attila, Bibli, Sofia-Iris, Papapetropoulos, Andreas, Szabo, Csaba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772643/
https://www.ncbi.nlm.nih.gov/pubmed/29343810
http://dx.doi.org/10.1038/s41598-018-19216-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772643/
https://www.ncbi.nlm.nih.gov/pubmed/29343810
http://dx.doi.org/10.1038/s41598-018-19216-1

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