PARP-1 Inhibition Rescues Short Lifespan in Hyperglycemic C. Elegans And Improves GLP-1 Secretion in Human Cells

TCF7L2 is located at one of the most strongly associated type 2 diabetes loci reported to date. We previously reported that the most abundant member of a specific protein complex to bind across the presumed causal variant at this locus, rs7903146, was poly [ADP-ribose] polymerase type 1 (PARP-1). We...

Descripción completa

Detalles Bibliográficos
Autores principales: Xia, Qianghua, Lu, Sumei, Ostrovsky, Julian, McCormack, Shana E, Falk, Marni J, Grant, Struan F. A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JKL International LLC 2018
Materias:
Orginal Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772855/
https://www.ncbi.nlm.nih.gov/pubmed/29392078
http://dx.doi.org/10.14336/AD.2017.0230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772855/
https://www.ncbi.nlm.nih.gov/pubmed/29392078
http://dx.doi.org/10.14336/AD.2017.0230

Ejemplares similares