Cargando…
Computational study of HIV gp120 as a target for polyanionic entry inhibitors: Exploiting the V3 loop region
Multiple approaches are being utilized to develop therapeutics to treat HIV infection. One approach is designed to inhibit entry of HIV into host cells, with a target being the viral envelope glycoprotein, gp120. Polyanionic compounds have been shown to be effective in inhibiting HIV entry, with a m...
Autores principales: | Hollingsworth, Louis R., Brown, Anne M., Gandour, Richard D., Bevan, David R. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773097/ https://www.ncbi.nlm.nih.gov/pubmed/29346393 http://dx.doi.org/10.1371/journal.pone.0190658 |
Ejemplares similares
-
Development of Protein- and Peptide-Based HIV Entry Inhibitors Targeting gp120 or gp41
por: Pu, Jing, et al.
Publicado: (2019) -
Effect of Lysine to Arginine Mutagenesis in the V3 Loop of HIV-1 gp120 on Viral Entry Efficiency and Neutralization
por: Schwalbe, Birco, et al.
Publicado: (2015) -
Conformation-dependent recognition of HIV Gp120 by DARPins provides novel possibilities to develop distinct HIV entry inhibitors
por: Mann, AM, et al.
Publicado: (2012) -
Interaction of the gp120 V1V2 loop with a neighboring gp120 unit shields the HIV envelope trimer against cross-neutralizing antibodies
por: Rusert, Peter, et al.
Publicado: (2011) -
Molecular Recognition of CCR5 by an HIV-1 gp120 V3 Loop
por: Tamamis, Phanourios, et al.
Publicado: (2014)