Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors

The lentiviral protein Viral Infectivity Factor (Vif) counteracts the antiviral effects of host APOBEC3 (A3) proteins and contributes to persistent HIV infection. Vif targets A3 restriction factors for ubiquitination and proteasomal degradation by recruiting them to a multi-protein ubiquitin E3 liga...

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Detalles Bibliográficos
Autores principales: Binning, Jennifer M., Smith, Amber M., Hultquist, Judd F., Craik, Charles S., Caretta Cartozo, Nathalie, Campbell, Melody G., Burton, Lily, La Greca, Florencia, McGregor, Michael J., Ta, Hai M., Bartholomeeusen, Koen, Peterlin, B. Matija, Krogan, Nevan J., Sevillano, Natalia, Cheng, Yifan, Gross, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773222/
https://www.ncbi.nlm.nih.gov/pubmed/29304101
http://dx.doi.org/10.1371/journal.ppat.1006830

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773222/
https://www.ncbi.nlm.nih.gov/pubmed/29304101
http://dx.doi.org/10.1371/journal.ppat.1006830

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