BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes

Bloom syndrome is a cancer predisposition disorder caused by mutations in the BLM helicase gene. Cells from persons with Bloom syndrome exhibit striking genomic instability characterized by excessive sister chromatid exchange events (SCEs). We applied single-cell DNA template strand sequencing (Stra...

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Detalles Bibliográficos
Autores principales: van Wietmarschen, Niek, Merzouk, Sarra, Halsema, Nancy, Spierings, Diana C. J., Guryev, Victor, Lansdorp, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773480/
https://www.ncbi.nlm.nih.gov/pubmed/29348659
http://dx.doi.org/10.1038/s41467-017-02760-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773480/
https://www.ncbi.nlm.nih.gov/pubmed/29348659
http://dx.doi.org/10.1038/s41467-017-02760-1

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