Cargando…

Dynamic cellular maps of molecular species: Application to drug-target interactions

The design of living cell studies aimed at deciphering the mechanism of action of drugs targeting proteins with multiple functions, expressed in a wide range of concentrations and cellular locations, is a real challenge. We recently showed that the antitumor drug plitidepsin (APL) localizes sufficie...

Descripción completa

Detalles Bibliográficos
Autores principales:	García, Carolina, Losada, Alejandro, Sacristán, Miguel A., Martínez-Leal, Juan Fernando, Galmarini, Carlos M., Lillo, M. Pilar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773516/ https://www.ncbi.nlm.nih.gov/pubmed/29348621 http://dx.doi.org/10.1038/s41598-018-19694-3

Ejemplares similares

Translation Elongation Factor eEF1A2 is a Novel Anticancer Target for the Marine Natural Product Plitidepsin
por: Losada, Alejandro, et al.
Publicado: (2016)

Elisidepsin Interacts Directly with Glycosylceramides in the Plasma Membrane of Tumor Cells to Induce Necrotic Cell Death
por: Molina-Guijarro, José Manuel, et al.
Publicado: (2015)

Binding of eEF1A2 to the RNA-dependent protein kinase PKR modulates its activity and promotes tumour cell survival
por: Losada, Alejandro, et al.
Publicado: (2018)

Plocabulin, a novel tubulin-binding agent, inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells
por: Galmarini, Carlos M., et al.
Publicado: (2018)

Irvalec Inserts into the Plasma Membrane Causing Rapid Loss of Integrity and Necrotic Cell Death in Tumor Cells
por: Molina-Guijarro, José M., et al.
Publicado: (2011)

Trabectedin and Plitidepsin: Drugs from the Sea that Strike the Tumor Microenvironment
por: Galmarini, Carlos M., et al.
Publicado: (2014)

Temperature-induced melting of double-stranded DNA in the absence and presence of covalently bonded antitumour drugs: insight from molecular dynamics simulations
por: Bueren-Calabuig, Juan A., et al.
Publicado: (2011)

Occurrence and Quantification of Antimicrobial Resistance Genes in the Gastrointestinal Microbiome of Two Wild Seabird Species With Contrasting Behaviors
por: Ewbank, Ana Carolina, et al.
Publicado: (2021)

Lessons from Hippocrates: Time to Change the Cancer Paradigm
por: Galmarini, Carlos M.
Publicado: (2020)

Why we do what we do. A brief analysis of cancer therapies
por: Galmarini, Carlos M.
Publicado: (2020)

Drug resistance associated with loss of p53 involves extensive alterations in microtubule composition and dynamics
por: Galmarini, C M, et al.
Publicado: (2003)

Mapping the pathophysiology of schizophrenia: interactions between multiple cellular pathways
por: Deng, Chao, et al.
Publicado: (2013)

Molecular basis of resistance to the microtubule-depolymerizing antitumor compound plocabulin
por: Pantazopoulou, Areti, et al.
Publicado: (2018)

Trabectedin, a drug acting on both cancer cells and the tumour microenvironment
por: D'Incalci, M, et al.
Publicado: (2014)

Improvement of Contact Tracing with Citizen’s Distributed Risk Maps
por: Rebollo, Miguel, et al.
Publicado: (2021)

Multiple coordinated cellular dynamics mediate CA1 map plasticity
por: Mizuta, Kotaro, et al.
Publicado: (2021)

Interactions between mitochondrial reactive oxygen species and cellular glucose metabolism
por: Liemburg-Apers, Dania C., et al.
Publicado: (2015)

Cellular and environmental dynamics influence species-specific extents of organelle gene retention
por: García Pascual, Belén, et al.
Publicado: (2023)

The olfactory Olfr-78/51E2 receptor interacts with the adenosine A(2A) receptor. Effect of menthol and 1,8-cineole on A(2A) receptor-mediated signaling
por: Lillo, Jaume, et al.
Publicado: (2023)

A fluorescent reporter for mapping cellular protein-protein interactions in time and space
por: Moreno, Daniel, et al.
Publicado: (2013)

Genome-wide Mapping of Cellular Protein–RNA Interactions Enabled by Chemical Crosslinking
por: Li, Xiaoyu, et al.
Publicado: (2014)

Analysis of transcriptomic responses to SARS-CoV-2 reveals plausible defective pathways responsible for increased susceptibility to infection and complications and helps to develop fast-track repositioning of drugs against COVID-19
por: deAndrés-Galiana, Enrique J., et al.
Publicado: (2022)

Genetic variation in foundation species governs the dynamics of trophic interactions
por: Valencia-Cuevas, Leticia, et al.
Publicado: (2018)

Aggressive bodyguards are not always the best: Preferential interaction with more aggressive ant species reduces reproductive success of plant bearing extrafloral nectaries
por: Melati, Bruno Gabriel, et al.
Publicado: (2018)

Mapping the electrostatic profiles of cellular membranes
por: Eisenberg, Sharon, et al.
Publicado: (2021)

iNR-Drug: Predicting the Interaction of Drugs with Nuclear Receptors in Cellular Networking
por: Fan, Yue-Nong, et al.
Publicado: (2014)

Medinillatheresae (Melastomataceae), a new species from ultramafic soils in the Philippines
por: Fernando, Edwino S., et al.
Publicado: (2018)

Mapping the Spatiotemporal Dynamics of Calcium Signaling in Cellular Neural Networks Using Optical Flow
por: Buibas, Marius, et al.
Publicado: (2010)

Adenosine A(2A) and A(3) Receptors Are Able to Interact with Each Other. A Further Piece in the Puzzle of Adenosine Receptor-Mediated Signaling
por: Lillo, Alejandro, et al.
Publicado: (2020)

The role of biological fluid and dynamic flow in the behavior and cellular interactions of gold nanoparticles
por: Breitner, Emily K., et al.
Publicado: (2015)

Carbon Dots–Biomembrane Interactions and Their Implications for Cellular Drug Delivery
por: Mavroidi, Barbara, et al.
Publicado: (2023)

Interaction molecular QTL mapping discovers cellular and environmental modifiers of genetic regulatory effects
por: Kasela, Silva, et al.
Publicado: (2023)

Editorial: Mapping the pathophysiology of schizophrenia: interactions between multiple cellular pathways, volume II
por: Matosin, Natalie, et al.
Publicado: (2023)

High resolution dynamic mapping of histone-DNA interactions in a nucleosome
por: Hall, Michael A., et al.
Publicado: (2009)

Cellular Alterations in Carbohydrate and Lipid Metabolism Due to Interactions with Nanomaterials
por: Martín-Pardillos, Ana, et al.
Publicado: (2023)

Dynamical Task Switching in Cellular Computers
por: Goñi-Moreno, Angel, et al.
Publicado: (2019)

The complex interactions of Chs5p, the ChAPs, and the cargo Chs3p
por: Rockenbauch, Uli, et al.
Publicado: (2012)

Ghrelin and Cannabinoid Functional Interactions Mediated by Ghrelin/CB(1) Receptor Heteromers That Are Upregulated in the Striatum From Offspring of Mice Under a High-Fat Diet
por: Lillo, Alejandro, et al.
Publicado: (2021)

Mutant Huntingtin Protein Interaction Map Implicates Dysregulation of Multiple Cellular Pathways in Neurodegeneration of Huntington’s Disease
por: Podvin, Sonia, et al.
Publicado: (2022)

Infomap Bioregions: Interactive Mapping of Biogeographical Regions from Species Distributions
por: Edler, Daniel, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_g5s3han6b6gtvcnmq6a3g5445v