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Identification of a membrane-less compartment regulating invadosome function and motility

Depletion of liprin-α1, ERC1 or LL5 scaffolds inhibits extracellular matrix degradation by invasive cells. These proteins co-accumulate near invadosomes in NIH-Src cells, identifying a novel invadosome–associated compartment distinct from the core and adhesion ring of invadosomes. Depletion of eithe...

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Detalles Bibliográficos
Autores principales: Sala, Kristyna, Raimondi, Andrea, Tonoli, Diletta, Tacchetti, Carlo, de Curtis, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773524/
https://www.ncbi.nlm.nih.gov/pubmed/29348417
http://dx.doi.org/10.1038/s41598-018-19447-2