Cargando…

Chikungunya virus nsP1 interacts directly with nsP2 and modulates its ATPase activity

Chikungunya virus (CHIKV) is a mosquito-borne virus, which has created an alarming threat in the world due to unavailability of vaccine and antiviral compounds. The CHIKV nsP2 contains ATPase, RTPase, helicase and protease activities, whereas, nsP1 is a viral capping enzyme. In alphaviruses, the fou...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kumar, Sameer, Kumar, Abhishek, Mamidi, Prabhudutta, Tiwari, Atul, Kumar, Sriram, Mayavannan, Animamalar, Mudulli, Sagarika, Singh, Ajit Kumar, Subudhi, Bharat Bhusan, Chattopadhyay, Soma
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773547/ https://www.ncbi.nlm.nih.gov/pubmed/29348627 http://dx.doi.org/10.1038/s41598-018-19295-0

Ejemplares similares

MBZM-N-IBT, a Novel Small Molecule, Restricts Chikungunya Virus Infection by Targeting nsP2 Protease Activity In Vitro, In Vivo, and Ex Vivo
por: De, Saikat, et al.
Publicado: (2022)

Heat Shock Protein 90 Positively Regulates Chikungunya Virus Replication by Stabilizing Viral Non-Structural Protein nsP2 during Infection
por: Das, Indrani, et al.
Publicado: (2014)

Analysis of chikungunya virus proteins reveals that non-structural proteins nsP2 and nsP3 exhibit RNA interference (RNAi) suppressor activity
por: Mathur, Kalika, et al.
Publicado: (2016)

Expression and biochemical characterization of nsP2 cysteine protease of Chikungunya virus
por: Pastorino, Boris A.M., et al.
Publicado: (2008)

Sindbis Virus nsP2 Endopeptidase
por: Strauss, Ellen G., et al.
Publicado: (2013)

Full length and protease domain activity of chikungunya virus nsP2 differ from other alphavirus nsP2 proteases in recognition of small peptide substrates
por: Saisawang, Chonticha, et al.
Publicado: (2015)

A model to study the inhibition of nsP2B-nsP3 protease of dengue virus with imidazole, oxazole, triazole thiadiazole, and thiazolidine based scaffolds
por: Vishvakarma, Vijay Kumar, et al.
Publicado: (2019)

NTPase and 5′-RNA Triphosphatase Activities of Chikungunya Virus nsP2 Protein
por: Karpe, Yogesh A., et al.
Publicado: (2011)

Discovery of in silico hits targeting the nsP3 macro domain of chikungunya virus
por: Nguyen, Phuong T. V., et al.
Publicado: (2014)

1,3-Thiazolbenzamide Derivatives as Chikungunya Virus nsP2 Protease Inhibitors
por: Ivanova, Larisa, et al.
Publicado: (2021)

P38 and JNK Mitogen-Activated Protein Kinases Interact With Chikungunya Virus Non-structural Protein-2 and Regulate TNF Induction During Viral Infection in Macrophages
por: Nayak, Tapas Kumar, et al.
Publicado: (2019)

Structural basis and dynamics of Chikungunya alphavirus RNA capping by nsP1 capping pores
por: Jones, Rhian, et al.
Publicado: (2023)

Inhibition of Chikungunya Virus Replication by 1-[(2-Methylbenzimidazol-1-yl) Methyl]-2-Oxo-Indolin-3-ylidene] Amino] Thiourea(MBZM-N-IBT)
por: Mishra, Priyadarsee, et al.
Publicado: (2016)

Interactions of Alphavirus nsP3 Protein with Host Proteins
por: Lark, Tyler, et al.
Publicado: (2018)

Molecular Modeling and Docking Study to Elucidate Novel Chikungunya Virus nsP2 Protease Inhibitors
por: Agarwal, T., et al.
Publicado: (2015)

Mosquito Rasputin interacts with chikungunya virus nsP3 and determines the infection rate in Aedes albopictus
por: Fros, Jelke J., et al.
Publicado: (2015)

The viral capping enzyme nsP1: a novel target for the inhibition of chikungunya virus infection
por: Delang, L., et al.
Publicado: (2016)

Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design
por: Zhang, Sixue, et al.
Publicado: (2021)

Development of nsP2 protease based cell free high throughput screening assay for evaluation of inhibitors against emerging Chikungunya virus
por: Saha, Amrita, et al.
Publicado: (2018)

Computational approach to study the synthesis of noscapine and potential of stereoisomers against nsP3 protease of CHIKV
por: Singh, Prashant, et al.
Publicado: (2019)

Conserved motifs in the hypervariable domain of chikungunya virus nsP3 required for transmission by Aedes aegypti mosquitoes
por: Göertz, Giel P., et al.
Publicado: (2018)

Evaluation of the Antiviral Potential of Halogenated Dihydrorugosaflavonoids and Molecular Modeling with nsP3 Protein of Chikungunya Virus (CHIKV)
por: Puranik, Ninad V., et al.
Publicado: (2019)

Insights into the role of the cobalt(III)-thiosemicarbazone complex as a potential inhibitor of the Chikungunya virus nsP4
por: Martins, Daniel Oliveira Silva, et al.
Publicado: (2022)

Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease’s active site cysteine residue
por: Rausalu, Kai, et al.
Publicado: (2016)

A Sensitive and Robust High-Throughput Screening Assay for Inhibitors of the Chikungunya Virus nsP1 Capping Enzyme
por: Bullard-Feibelman, Kristen M., et al.
Publicado: (2016)

Mono-ADP-ribosylation by PARP10 inhibits Chikungunya virus nsP2 proteolytic activity and viral replication
por: Krieg, Sarah, et al.
Publicado: (2023)

Identification of the active site residues in the nsP2 proteinase of sindbis virus
por: Strauss, Ellen G., et al.
Publicado: (1992)

DNA Damage Response Signaling Is Crucial for Effective Chikungunya Virus Replication
por: Chatterjee, Sanchari, et al.
Publicado: (2022)

Current Strategies for Inhibition of Chikungunya Infection
por: Subudhi, Bharat Bhusan, et al.
Publicado: (2018)

Chikungunya Virus Overcomes Polyamine Depletion by Mutation of nsP1 and the Opal Stop Codon To Confer Enhanced Replication and Fitness
por: Mounce, Bryan C., et al.
Publicado: (2017)

Targeted in vitro gene silencing of E2 and nsP1 genes of chikungunya virus by biocompatible zeolitic imidazolate framework
por: Tagore, Rajarshee, et al.
Publicado: (2022)

Capping pores of alphavirus nsP1 gate membranous viral replication factories
por: Jones, Rhian, et al.
Publicado: (2020)

nsP4 Is a Major Determinant of Alphavirus Replicase Activity and Template Selectivity
por: Lello, Laura Sandra, et al.
Publicado: (2021)

Expression of Plasmid-Based shRNA against the E1 and nsP1 Genes Effectively Silenced Chikungunya Virus Replication
por: Lam, Shirley, et al.
Publicado: (2012)

Chikungunya nsP2 protease is not a papain-like cysteine protease and the catalytic dyad cysteine is interchangeable with a proximal serine
por: Saisawang, Chonticha, et al.
Publicado: (2015)

Cell-Type-Dependent Role for nsP3 Macrodomain ADP-Ribose Binding and Hydrolase Activity during Chikungunya Virus Infection
por: Kim, Taewoo, et al.
Publicado: (2022)

The nsP3 macro domain is important for Sindbis virus replication in neurons and neurovirulence in mice
por: Park, Eunhye, et al.
Publicado: (2009)

Cooperative translocation enhances the unwinding of duplex DNA by SARS coronavirus helicase nsP13
por: Lee, Na-Ra, et al.
Publicado: (2010)

Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13
por: Yu, Mi-Sun, et al.
Publicado: (2012)

Differential unfolded protein response during Chikungunya and Sindbis virus infection: CHIKV nsP4 suppresses eIF2α phosphorylation
por: Rathore, Abhay P S, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_3nbjlaq5pa5oam17fp45s94f7h