Cytokine-mediated changes in K(+) channel activity promotes an adaptive Ca(2+) response that sustains β-cell insulin secretion during inflammation

Cytokines present during low-grade inflammation contribute to β-cell dysfunction and diabetes. Cytokine signaling disrupts β-cell glucose-stimulated Ca(2+) influx (GSCI) and endoplasmic reticulum (ER) Ca(2+) ([Ca(2+)](ER)) handling, leading to diminished glucose-stimulated insulin secretion (GSIS)....

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Detalles Bibliográficos
Autores principales: Dickerson, Matthew T., Bogart, Avery M., Altman, Molly K., Milian, Sarah C., Jordan, Kelli L., Dadi, Prasanna K., Jacobson, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773563/
https://www.ncbi.nlm.nih.gov/pubmed/29348619
http://dx.doi.org/10.1038/s41598-018-19600-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773563/
https://www.ncbi.nlm.nih.gov/pubmed/29348619
http://dx.doi.org/10.1038/s41598-018-19600-x

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