A synthetic combinatorial approach to disabling deviant Hedgehog signaling

Mutations in components of the Hedgehog (HH) signal transduction pathway are found in the majority of basal cell carcinoma (BCC) and medulloblastoma incidents. Cancerous cells with intrinsic or acquired resistance to antagonists targeting the seven transmembrane effector Smoothened (SMO) frequently...

Descripción completa

Detalles Bibliográficos
Autores principales: Fan, C-W., Yarravarapu, N., Shi, H., Kulak, O., Kim, J., Chen, C., Lum, L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773580/
https://www.ncbi.nlm.nih.gov/pubmed/29348431
http://dx.doi.org/10.1038/s41598-018-19408-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773580/
https://www.ncbi.nlm.nih.gov/pubmed/29348431
http://dx.doi.org/10.1038/s41598-018-19408-9

Ejemplares similares