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Redundancy of protein disulfide isomerases in the catalysis of the inactivating disulfide switch in A Disintegrin and Metalloprotease 17

A Disintegrin and Metalloprotease 17 (ADAM17) can cause the fast release of growth factors and inflammatory mediators from the cell surface. Its activity has to be turned on which occurs by various stimuli. The active form can be inactivated by a structural change in its ectodomain, related to the p...

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Detalles Bibliográficos
Autores principales: Krossa, Sebastian, Scheidig, Axel J., Grötzinger, Joachim, Lorenzen, Inken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773583/
https://www.ncbi.nlm.nih.gov/pubmed/29348576
http://dx.doi.org/10.1038/s41598-018-19429-4