Specific cyclic ADP-ribose phosphohydrolase obtained by mutagenic engineering of Mn(2+)-dependent ADP-ribose/CDP-alcohol diphosphatase

Cyclic ADP-ribose (cADPR) is a messenger for Ca(2+) mobilization. Its turnover is believed to occur by glycohydrolysis to ADP-ribose. However, ADP-ribose/CDP-alcohol diphosphatase (ADPRibase-Mn) acts as cADPR phosphohydrolase with much lower efficiency than on its major substrates. Recently, we show...

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Detalles Bibliográficos
Autores principales: Ribeiro, João Meireles, Canales, José, Cabezas, Alicia, Rodrigues, Joaquim Rui, Pinto, Rosa María, López-Villamizar, Iralis, Costas, María Jesús, Cameselle, José Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773619/
https://www.ncbi.nlm.nih.gov/pubmed/29348648
http://dx.doi.org/10.1038/s41598-017-18393-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773619/
https://www.ncbi.nlm.nih.gov/pubmed/29348648
http://dx.doi.org/10.1038/s41598-017-18393-9

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