Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity

Zoledronate is a bisphosphonate that is widely used in the treatment of metabolic bone diseases. However, zoledronate induces significant nephrotoxicity associated with acute tubular necrosis and renal fibrosis when administered intravenously. There is speculation that zoledronate-induced nephrotoxi...

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Detalles Bibliográficos
Autores principales: Cheng, Lili, Ge, Mengmeng, Lan, Zhou, Ma, Zhilong, Chi, Wenna, Kuang, Wenhua, Sun, Kun, Zhao, Xinbin, Liu, Ye, Feng, Yaqian, Huang, Yuedong, Luo, Maoguo, Li, Liping, Zhang, Bin, Hu, Xiaoyu, Xu, Lina, Liu, Xiaohui, Huo, Yi, Deng, Haiteng, Yang, Jinliang, Xi, Qiaoran, Zhang, Yonghui, Siegenthaler, Julie A., Chen, Ligong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Organ Toxicity and Mechanisms
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773652/
https://www.ncbi.nlm.nih.gov/pubmed/28871336
http://dx.doi.org/10.1007/s00204-017-2048-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773652/
https://www.ncbi.nlm.nih.gov/pubmed/28871336
http://dx.doi.org/10.1007/s00204-017-2048-0

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