BPDE-induced genotoxicity: relationship between DNA adducts, mutagenicity in the in vitro PIG-A assay, and the transcriptional response to DNA damage in TK6 cells

Benzo[a]pyrene is a known human carcinogen. As underlying mechanism, the induction of stable DNA adducts and mutations have been repeatedly demonstrated. Also, the activation of cellular stress response on the transcriptional level has been described. Nevertheless, the interrelationship between thes...

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Detalles Bibliográficos
Autores principales: Piberger, Ann Liza, Krüger, Christopher T., Strauch, Bettina M., Schneider, Beatrice, Hartwig, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Genotoxicity and Carcinogenicity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773665/
https://www.ncbi.nlm.nih.gov/pubmed/28593498
http://dx.doi.org/10.1007/s00204-017-2003-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773665/
https://www.ncbi.nlm.nih.gov/pubmed/28593498
http://dx.doi.org/10.1007/s00204-017-2003-0

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