Theoretical models of inhibitory activity for inhibitors of protein–protein interactions: targeting menin–mixed lineage leukemia with small molecules

Development and binding affinity predictions of inhibitors targeting protein–protein interactions (PPI) still represent a major challenge in drug discovery efforts. This work reports application of a predictive non-empirical model of inhibitory activity for PPI inhibitors, exemplified here for small...

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Detalles Bibliográficos
Autores principales: Jedwabny, Wiktoria, Kłossowski, Szymon, Purohit, Trupta, Cierpicki, Tomasz, Grembecka, Jolanta, Dyguda-Kazimierowicz, Edyta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774433/
https://www.ncbi.nlm.nih.gov/pubmed/29456828
http://dx.doi.org/10.1039/c7md00170c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774433/
https://www.ncbi.nlm.nih.gov/pubmed/29456828
http://dx.doi.org/10.1039/c7md00170c

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