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Clinical and microbiologic efficacy of the piperazine-based drug lead MMV665917 in the dairy calf cryptosporidiosis model

Cryptosporidiosis causes life-threatening diarrhea in infants, but the best available treatment is only modestly efficacious. Rodents infected with relevant Cryptosporidium species do not develop diarrhea, which complicates drug development. Cryptosporidium parvum infection of dairy calves, however,...

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Detalles Bibliográficos
Autores principales: Stebbins, Erin, Jumani, Rajiv S., Klopfer, Connor, Barlow, John, Miller, Peter, Campbell, Mary A., Meyers, Marvin J., Griggs, David W., Huston, Christopher D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774826/
https://www.ncbi.nlm.nih.gov/pubmed/29309415
http://dx.doi.org/10.1371/journal.pntd.0006183