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Clinical and microbiologic efficacy of the piperazine-based drug lead MMV665917 in the dairy calf cryptosporidiosis model
Cryptosporidiosis causes life-threatening diarrhea in infants, but the best available treatment is only modestly efficacious. Rodents infected with relevant Cryptosporidium species do not develop diarrhea, which complicates drug development. Cryptosporidium parvum infection of dairy calves, however,...
Autores principales: | Stebbins, Erin, Jumani, Rajiv S., Klopfer, Connor, Barlow, John, Miller, Peter, Campbell, Mary A., Meyers, Marvin J., Griggs, David W., Huston, Christopher D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774826/ https://www.ncbi.nlm.nih.gov/pubmed/29309415 http://dx.doi.org/10.1371/journal.pntd.0006183 |
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