Stereochemistry and amyloid inhibition: Asymmetric triplex metallohelices enantioselectively bind to Aβ peptide

Stereochemistry is vital for pharmaceutical development and can determine drug efficacy. Herein, 10 pairs of asymmetric triplex metallohelix enantiomers as a library were used to screen inhibitors of amyloid β (Aβ) aggregation via a fluorescent cell–based high-throughput method. Intriguingly, Λ enan...

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Detalles Bibliográficos
Autores principales: Guan, Yijia, Du, Zhi, Gao, Nan, Cao, Yue, Wang, Xiaohui, Scott, Peter, Song, Hualong, Ren, Jinsong, Qu, Xiaogang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775025/
https://www.ncbi.nlm.nih.gov/pubmed/29372182
http://dx.doi.org/10.1126/sciadv.aao6718

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775025/
https://www.ncbi.nlm.nih.gov/pubmed/29372182
http://dx.doi.org/10.1126/sciadv.aao6718

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