Compositional Bias in Naïve and Chemically-modified Phage-Displayed Libraries uncovered by Paired-end Deep Sequencing

Understanding the composition of a genetically-encoded (GE) library is instrumental to the success of ligand discovery. In this manuscript, we investigate the bias in GE-libraries of linear, macrocyclic and chemically post-translationally modified (cPTM) tetrapeptides displayed on the M13KE platform...

Descripción completa

Detalles Bibliográficos
Autores principales: He, Bifang, Tjhung, Katrina F., Bennett, Nicholas J., Chou, Ying, Rau, Andrea, Huang, Jian, Derda, Ratmir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775325/
https://www.ncbi.nlm.nih.gov/pubmed/29352178
http://dx.doi.org/10.1038/s41598-018-19439-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775325/
https://www.ncbi.nlm.nih.gov/pubmed/29352178
http://dx.doi.org/10.1038/s41598-018-19439-2

Ejemplares similares