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Compositional Bias in Naïve and Chemically-modified Phage-Displayed Libraries uncovered by Paired-end Deep Sequencing

Understanding the composition of a genetically-encoded (GE) library is instrumental to the success of ligand discovery. In this manuscript, we investigate the bias in GE-libraries of linear, macrocyclic and chemically post-translationally modified (cPTM) tetrapeptides displayed on the M13KE platform...

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Detalles Bibliográficos
Autores principales:	He, Bifang, Tjhung, Katrina F., Bennett, Nicholas J., Chou, Ying, Rau, Andrea, Huang, Jian, Derda, Ratmir
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775325/ https://www.ncbi.nlm.nih.gov/pubmed/29352178 http://dx.doi.org/10.1038/s41598-018-19439-2

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