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Advanced LC–MS-based methods to study the co-occurrence and metabolization of multiple mycotoxins in cereals and cereal-based food
Liquid chromatography (LC) coupled with mass spectrometry (MS) is widely used for the determination of mycotoxins in cereals and cereal-based products. In addition to the regulated mycotoxins, for which official control is required, LC–MS is often used for the screening of a large range of mycotoxin...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775372/ https://www.ncbi.nlm.nih.gov/pubmed/29273904 http://dx.doi.org/10.1007/s00216-017-0750-7 |
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author | Malachová, Alexandra Stránská, Milena Václavíková, Marta Elliott, Christopher T. Black, Connor Meneely, Julie Hajšlová, Jana Ezekiel, Chibundu N. Schuhmacher, Rainer Krska, Rudolf |
author_facet | Malachová, Alexandra Stránská, Milena Václavíková, Marta Elliott, Christopher T. Black, Connor Meneely, Julie Hajšlová, Jana Ezekiel, Chibundu N. Schuhmacher, Rainer Krska, Rudolf |
author_sort | Malachová, Alexandra |
collection | PubMed |
description | Liquid chromatography (LC) coupled with mass spectrometry (MS) is widely used for the determination of mycotoxins in cereals and cereal-based products. In addition to the regulated mycotoxins, for which official control is required, LC–MS is often used for the screening of a large range of mycotoxins and/or for the identification and characterization of novel metabolites. This review provides insight into the LC–MS methods used for the determination of co-occurring mycotoxins with special emphasis on multiple-analyte applications. The first part of the review is focused on targeted LC–MS approaches using cleanup methods such as solid-phase extraction and immunoaffinity chromatography, as well as on methods based on minimum cleanup (quick, easy, cheap, effective, rugged, and safe; QuEChERS) and dilute and shoot. The second part of the review deals with the untargeted determination of mycotoxins by LC coupled with high-resolution MS, which includes also metabolomics techniques to study the fate of mycotoxins in plants. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00216-017-0750-7) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5775372 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-57753722018-01-30 Advanced LC–MS-based methods to study the co-occurrence and metabolization of multiple mycotoxins in cereals and cereal-based food Malachová, Alexandra Stránská, Milena Václavíková, Marta Elliott, Christopher T. Black, Connor Meneely, Julie Hajšlová, Jana Ezekiel, Chibundu N. Schuhmacher, Rainer Krska, Rudolf Anal Bioanal Chem Review Liquid chromatography (LC) coupled with mass spectrometry (MS) is widely used for the determination of mycotoxins in cereals and cereal-based products. In addition to the regulated mycotoxins, for which official control is required, LC–MS is often used for the screening of a large range of mycotoxins and/or for the identification and characterization of novel metabolites. This review provides insight into the LC–MS methods used for the determination of co-occurring mycotoxins with special emphasis on multiple-analyte applications. The first part of the review is focused on targeted LC–MS approaches using cleanup methods such as solid-phase extraction and immunoaffinity chromatography, as well as on methods based on minimum cleanup (quick, easy, cheap, effective, rugged, and safe; QuEChERS) and dilute and shoot. The second part of the review deals with the untargeted determination of mycotoxins by LC coupled with high-resolution MS, which includes also metabolomics techniques to study the fate of mycotoxins in plants. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00216-017-0750-7) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2017-12-22 2018 /pmc/articles/PMC5775372/ /pubmed/29273904 http://dx.doi.org/10.1007/s00216-017-0750-7 Text en © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Review Malachová, Alexandra Stránská, Milena Václavíková, Marta Elliott, Christopher T. Black, Connor Meneely, Julie Hajšlová, Jana Ezekiel, Chibundu N. Schuhmacher, Rainer Krska, Rudolf Advanced LC–MS-based methods to study the co-occurrence and metabolization of multiple mycotoxins in cereals and cereal-based food |
title | Advanced LC–MS-based methods to study the co-occurrence and metabolization of multiple mycotoxins in cereals and cereal-based food |
title_full | Advanced LC–MS-based methods to study the co-occurrence and metabolization of multiple mycotoxins in cereals and cereal-based food |
title_fullStr | Advanced LC–MS-based methods to study the co-occurrence and metabolization of multiple mycotoxins in cereals and cereal-based food |
title_full_unstemmed | Advanced LC–MS-based methods to study the co-occurrence and metabolization of multiple mycotoxins in cereals and cereal-based food |
title_short | Advanced LC–MS-based methods to study the co-occurrence and metabolization of multiple mycotoxins in cereals and cereal-based food |
title_sort | advanced lc–ms-based methods to study the co-occurrence and metabolization of multiple mycotoxins in cereals and cereal-based food |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775372/ https://www.ncbi.nlm.nih.gov/pubmed/29273904 http://dx.doi.org/10.1007/s00216-017-0750-7 |
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