The action of a negative allosteric modulator at the dopamine D(2) receptor is dependent upon sodium ions

Sodium ions (Na(+)) allosterically modulate the binding of orthosteric agonists and antagonists to many class A G protein-coupled receptors, including the dopamine D(2) receptor (D(2)R). Experimental and computational evidences have revealed that this effect is mediated by the binding of Na(+) to a...

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Detalles Bibliográficos
Autores principales: Draper-Joyce, Christopher J., Verma, Ravi Kumar, Michino, Mayako, Shonberg, Jeremy, Kopinathan, Anitha, Klein Herenbrink, Carmen, Scammells, Peter J., Capuano, Ben, Abramyan, Ara M., Thal, David M., Javitch, Jonathan A., Christopoulos, Arthur, Shi, Lei, Lane, J. Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775417/
https://www.ncbi.nlm.nih.gov/pubmed/29352161
http://dx.doi.org/10.1038/s41598-018-19642-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775417/
https://www.ncbi.nlm.nih.gov/pubmed/29352161
http://dx.doi.org/10.1038/s41598-018-19642-1

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