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Differential effects of SUMO1 and SUMO3 on PKR activation and stability

Double-stranded RNA (dsRNA)-dependent protein kinase (PKR) is a serine/threonine kinase that exerts its own phosphorylation and the phosphorylation of the α subunit of the protein synthesis initiation factor eIF-2α. PKR was identified as a target of SUMOylation and the triple PKR-SUMO deficient muta...

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Detalles Bibliográficos
Autores principales: Maarifi, Ghizlane, El Asmi, Faten, Maroui, Mohamed Ali, Dianoux, Laurent, Chelbi-Alix, Mounira K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775435/
https://www.ncbi.nlm.nih.gov/pubmed/29352251
http://dx.doi.org/10.1038/s41598-018-19683-6