S-Ketamine Mediates Its Acute and Sustained Antidepressant-Like Activity through a 5-HT(1B) Receptor Dependent Mechanism in a Genetic Rat Model of Depression

Rationale: The mechanisms responsible for the unique antidepressant properties of ketamine have only been partly resolved. Recent preclinical reports implicate the neurotransmitter serotonin [5-hydroxytryptamine (5-HT)] in the antidepressant-like response of ketamine, and modulation of 5-HT(1B) rece...

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Detalles Bibliográficos
Autores principales: du Jardin, Kristian G., Liebenberg, Nico, Cajina, Manuel, Müller, Heidi K., Elfving, Betina, Sanchez, Connie, Wegener, Gregers
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775507/
https://www.ncbi.nlm.nih.gov/pubmed/29379439
http://dx.doi.org/10.3389/fphar.2017.00978

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775507/
https://www.ncbi.nlm.nih.gov/pubmed/29379439
http://dx.doi.org/10.3389/fphar.2017.00978

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