SETDB1 prevents TET2-dependent activation of IAP retroelements in naïve embryonic stem cells

BACKGROUND: Endogenous retroviruses (ERVs), which are responsible for 10% of spontaneous mouse mutations, are kept under control via several epigenetic mechanisms. The H3K9 histone methyltransferase SETDB1 is essential for ERV repression in embryonic stem cells (ESCs), with DNA methylation also play...

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Detalles Bibliográficos
Autores principales: Deniz, Özgen, de la Rica, Lorenzo, Cheng, Kevin C. L., Spensberger, Dominik, Branco, Miguel R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775534/
https://www.ncbi.nlm.nih.gov/pubmed/29351814
http://dx.doi.org/10.1186/s13059-017-1376-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775534/
https://www.ncbi.nlm.nih.gov/pubmed/29351814
http://dx.doi.org/10.1186/s13059-017-1376-y

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