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Molecular changes associated with increased TNF-α-induced apoptotis in naïve (T(N)) and central memory (T(CM)) CD8+ T cells in aged humans

BACKGROUND: Progressive T cell decline in aged humans is associated with a deficiency of naïve (T(N)) and central memory (T(CM)) T cells. We have previously reported increased Tumor necrosis factor-α (TNF-α)-induced apoptosis in T(N) and T(CM) T cells in aged humans; however, the molecular basis of...

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Detalles Bibliográficos
Autores principales: Gupta, Sudhir, Su, Houfen, Agrawal, Sudhanshu, Gollapudi, Sastry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775550/
https://www.ncbi.nlm.nih.gov/pubmed/29387134
http://dx.doi.org/10.1186/s12979-017-0109-0