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Molecular changes associated with increased TNF-α-induced apoptotis in naïve (T(N)) and central memory (T(CM)) CD8+ T cells in aged humans
BACKGROUND: Progressive T cell decline in aged humans is associated with a deficiency of naïve (T(N)) and central memory (T(CM)) T cells. We have previously reported increased Tumor necrosis factor-α (TNF-α)-induced apoptosis in T(N) and T(CM) T cells in aged humans; however, the molecular basis of...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775550/ https://www.ncbi.nlm.nih.gov/pubmed/29387134 http://dx.doi.org/10.1186/s12979-017-0109-0 |