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Histone demethylase PHF8 regulates hypoxia signaling through HIF1α and H3K4me3
Hypoxia through transcription factor HIF1α plays a critical role in cancer development. In prostate cancer, HIF1α interplays with androgen receptor (AR) to contribute to the progression of this disease to its lethal form—castration-resistant prostate cancer (CRPC). Hypoxia upregulates several epigen...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776039/ https://www.ncbi.nlm.nih.gov/pubmed/28734980 http://dx.doi.org/10.1016/j.bbagrm.2017.07.005 |