PSORS1C1 Hypomethylation Is Associated with Allopurinol-Induced Severe Cutaneous Adverse Reactions during Disease Onset Period: A Multicenter Retrospective Case-Control Clinical Study in Han Chinese

Background: Allopurinol-induced severe cutaneous adverse reactions (SCARs), including drug rash with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN), are life-threatening autoimmune reactions. Evidence is growing that epigenetic variation...

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Detalles Bibliográficos
Autores principales: Sun, Bao, Cheng, Lin, Xiong, Yan, Hu, Lei, Luo, Zhiying, Zhou, Maosong, Li, Ji, Xie, Hongfu, He, Fazhong, Yuan, Xiaoqing, Chen, Xiaoping, Zhou, Hong-Hao, Liu, Zhaoqian, Chen, Xiang, Zhang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776094/
https://www.ncbi.nlm.nih.gov/pubmed/29387007
http://dx.doi.org/10.3389/fphar.2017.00923

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776094/
https://www.ncbi.nlm.nih.gov/pubmed/29387007
http://dx.doi.org/10.3389/fphar.2017.00923

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