Cargando…

Abnormal Ergosterol Biosynthesis Activates Transcriptional Responses to Antifungal Azoles

Fungi transcriptionally upregulate expression of azole efflux pumps and ergosterol biosynthesis pathway genes when exposed to antifungal agents that target ergosterol biosynthesis. To date, these transcriptional responses have been shown to be dependent on the presence of the azoles and/or depletion...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Chengcheng, Zhou, Mi, Wang, Wenzhao, Sun, Xianyun, Yarden, Oded, Li, Shaojie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776110/ https://www.ncbi.nlm.nih.gov/pubmed/29387050 http://dx.doi.org/10.3389/fmicb.2018.00009

Ejemplares similares

Sterol C-22 Desaturase ERG5 Mediates the Sensitivity to Antifungal Azoles in Neurospora crassa and Fusarium verticillioides
por: Sun, Xianyun, et al.
Publicado: (2013)

Coordinated Regulation of Membrane Homeostasis and Drug Accumulation by Novel Kinase STK-17 in Response to Antifungal Azole Treatment
por: Hu, Chengcheng, et al.
Publicado: (2022)

De-repression of CSP-1 activates adaptive responses to antifungal azoles
por: Chen, Xi, et al.
Publicado: (2016)

Experimental Evolution of Multidrug Resistance in Neurospora crassa under Antifungal Azole Stress
por: Zhou, Mi, et al.
Publicado: (2022)

The Hsp90 Co-chaperones Sti1, Aha1, and P23 Regulate Adaptive Responses to Antifungal Azoles
por: Gu, Xiaokui, et al.
Publicado: (2016)

Ergosterol biosynthesis in Aspergillus fumigatus: its relevance as an antifungal target and role in antifungal drug resistance
por: Alcazar-Fuoli, Laura, et al.
Publicado: (2013)

Linkage between genes involved in azole resistance and ergosterol biosynthesis
por: Moye-Rowley, W. Scott
Publicado: (2020)

Requirement for Ergosterol in V-ATPase Function Underlies Antifungal Activity of Azole Drugs
por: Zhang, Yong-Qiang, et al.
Publicado: (2010)

Antifungal Activity of Minocycline and Azoles Against Fluconazole-Resistant Candida Species
por: Tan, Jingwen, et al.
Publicado: (2021)

The Aspergillus fumigatus Damage Resistance Protein Family Coordinately Regulates Ergosterol Biosynthesis and Azole Susceptibility
por: Song, Jinxing, et al.
Publicado: (2016)

The Zn(II)2Cys6-Type Transcription Factor ADA-6 Regulates Conidiation, Sexual Development, and Oxidative Stress Response in Neurospora crassa
por: Sun, Xianyun, et al.
Publicado: (2019)

Transcriptional regulation of ergosterol biosynthesis genes in response to iron deficiency
por: Jordá, Tania, et al.
Publicado: (2022)

Citronellal Exerts Its Antifungal Activity by Targeting Ergosterol Biosynthesis in Penicillium digitatum
por: OuYang, Qiuli, et al.
Publicado: (2021)

The Adr1 transcription factor directs regulation of the ergosterol pathway and azole resistance in Candida albicans
por: Shrivastava, Manjari, et al.
Publicado: (2023)

The genome and transcriptome of Sarocladium terricola provide insight into ergosterol biosynthesis
por: Wang, Wei, et al.
Publicado: (2023)

Azole Resistance in Aspergillus fumigatus: A Consequence of Antifungal Use in Agriculture?
por: Berger, Sarah, et al.
Publicado: (2017)

Mevalonate Diphosphate Decarboxylase MVD/Erg19 Is Required for Ergosterol Biosynthesis, Growth, Sporulation and Stress Tolerance in Aspergillus oryzae
por: Sun, Yunlong, et al.
Publicado: (2019)

Sanguinarine, Isolated From Macleaya cordata, Exhibits Potent Antifungal Efficacy Against Candida albicans Through Inhibiting Ergosterol Synthesis
por: Hu, Ziwei, et al.
Publicado: (2022)

Azole Antifungal Resistance in Candida albicans and Emerging Non-albicans Candida Species
por: Whaley, Sarah G., et al.
Publicado: (2017)

Regulation of Ergosterol Biosynthesis in Saccharomyces cerevisiae
por: Jordá, Tania, et al.
Publicado: (2020)

Characterization of the Ergosterol Biosynthesis Pathway in Ceratocystidaceae
por: Sayari, Mohammad, et al.
Publicado: (2021)

Phenotypic Analysis of Mutants of Ergosterol Biosynthesis Genes (ERG3 and ERG4) in the Red Yeast Xanthophyllomyces dendrorhous
por: Venegas, Maximiliano, et al.
Publicado: (2020)

Unraveling the importance of molecules of natural origin in antifungal drug development through targeting ergosterol biosynthesis pathway
por: Jamzivar, Fatemehsadat, et al.
Publicado: (2019)

Palmitic Acid Inhibits the Virulence Factors of Candida tropicalis: Biofilms, Cell Surface Hydrophobicity, Ergosterol Biosynthesis, and Enzymatic Activity
por: Prasath, Krishnan Ganesh, et al.
Publicado: (2020)

Coordinated Regulation of Protoperithecium Development by MAP Kinases MAK-1 and MAK-2 in Neurospora crassa
por: Lan, Nan, et al.
Publicado: (2021)

Synthesis, Biological Evaluation, and Structure–Activity Relationships of 4-Aminopiperidines as Novel Antifungal Agents Targeting Ergosterol Biosynthesis
por: Krauß, Jürgen, et al.
Publicado: (2021)

The Effect of Honokiol on Ergosterol Biosynthesis and Vacuole Function in Candida albicans
por: Sun, Lingmei, et al.
Publicado: (2020)

Evidence that Ergosterol Biosynthesis Modulates Activity of the Pdr1 Transcription Factor in Candida glabrata
por: Vu, Bao Gia, et al.
Publicado: (2019)

New Antifungal Agents with Azole Moieties
por: Teixeira, Melissa Martins, et al.
Publicado: (2022)

Aspergillus Species and Antifungals Susceptibility in Clinical Setting in the North of Portugal: Cryptic Species and Emerging Azoles Resistance in A. fumigatus
por: Pinto, Eugénia, et al.
Publicado: (2018)

Fungal association with sessile marine invertebrates
por: Yarden, Oded
Publicado: (2014)

The SET-domain protein CgSet4 negatively regulates antifungal drug resistance via the ergosterol biosynthesis transcriptional regulator CgUpc2a
por: Bhakt, Priyanka, et al.
Publicado: (2022)

In vitro and in vivo evaluation of antifungal combinations against azole-resistant Aspergillus fumigatus isolates
por: Jemel, Sana, et al.
Publicado: (2023)

Erg4 Is Involved in Ergosterol Biosynthesis, Conidiation and Stress Response in Penicillium expansum
por: Han, Zhanhong, et al.
Publicado: (2023)

In vitro and in vivo Study of Antifungal Effect of Pyrvinium Pamoate Alone and in Combination With Azoles Against Exophiala dermatitidis
por: Sun, Yi, et al.
Publicado: (2020)

Synergistic effects of tacrolimus and azole antifungal compounds in fluconazole-susceptible and fluconazole-resistant Candida glabrata isolates
por: Denardi, Laura Bedin, et al.
Publicado: (2015)

Influence of ergosterol and phytosterols on wine alcoholic fermentation with Saccharomyces cerevisiae strains
por: Girardi-Piva, Giovana, et al.
Publicado: (2022)

Quantifying Isoprenoids in the Ergosterol Biosynthesis by Gas Chromatography–Mass Spectrometry
por: Liebl, Maximilian, et al.
Publicado: (2023)

Recommendations on the use of azole antifungals in hematology-oncology patients
por: Azanza, José Ramón, et al.
Publicado: (2023)

Antifungal Activity and Synergism with Azoles of Polish Propolis
por: Gucwa, Katarzyna, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_gfava4o6lfi5mqatm18ktcgddd