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Intracerebroventricular Administration of (192)IgG-Saporin Alters Expression of Microglia-Associated Genes in the Dorsal But Not Ventral Hippocampus

One of important aspects of development of Alzheimer’s disease is degeneration of septal cholinergic neurons that innervate the hippocampus. We took advantage of widely used model of cholinergic deficit in the hippocampus, intracerebroventricular administration of (192)IgG-saporin (Ig-saporin), to a...

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Detalles Bibliográficos
Autores principales: Dobryakova, Yulia V., Kasianov, Artem, Zaichenko, Maria I., Stepanichev, Mikhail Y., Chesnokova, Ekaterina A., Kolosov, Petr M., Markevich, Vladimir A., Bolshakov, Alexey P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776139/
https://www.ncbi.nlm.nih.gov/pubmed/29386992
http://dx.doi.org/10.3389/fnmol.2017.00429