Shikonin causes apoptosis by disrupting intracellular calcium homeostasis and mitochondrial function in human hepatoma cells

Shikonin is known to suppress proliferation and induce apoptosis in a variety of cancer cell lines. In the present study, SMMC-7721 human hepatocellular carcinoma cells were treated with shikonin (1, 2 or 4 µM) for 12–48 h. Cell morphological alterations and DNA damage were determined. Furthermore,...

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Detalles Bibliográficos
Autores principales: Wang, Hui, Liu, Zheng, Li, Xiangchen, Zhao, Ruijie, Pu, Yabin, Wu, Handong, Guan, Weijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776525/
https://www.ncbi.nlm.nih.gov/pubmed/29434733
http://dx.doi.org/10.3892/etm.2017.5591

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776525/
https://www.ncbi.nlm.nih.gov/pubmed/29434733
http://dx.doi.org/10.3892/etm.2017.5591

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